Sean Clifford passed for four touchdowns and a career-high 401 yards, leading No. 6 Penn State to a 38-17 victory over Villanova.
Clifford completed 19 of 26 passes, finding Parker Washington for two TDs and Jahan Dotson and KeAndre Lambert-Smith for one apiece.
Tyler Warren rushed for a touchdown and Jordan Stout kicked a field goal for the Nittany Lions, who led 17-3 at the break in their eighth straight win.
Villanova quarterback Daniel Smith threw 57- and 17-yard touchdown passes to Rayjoun Pringle in the fourth.